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Guide

A Guide to Measuring Drug-Target Residence Times with Biochemical Assays

BellBrook-Article-June
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BellBrook-Article-June

During drug development initiatives, analysis of drug-target residence times can improve efficacy, increase therapeutic window, and reduce the risk of premature focus on candidate compounds that are likely to have undesirable side effects.

This guide provides technical background on concepts and techniques for use of Transcreener® biochemical assays to measure drug-target residence times, along with examples and case studies likely to have undesirable side effects.

Download this guide to learn about:

  • How residence time assays provide insight into drug-target interactions
  • The basics of transcreener assays
  • The different detection methods
  • Feasible and unfeasible target types
  • High-throughput drug residence time screening using jump-dilution kinetics