A Kinase Inhibitor Phenotypic Screen Using a Novel Multiplex T Cell Activation Assay

T cells play a critical role in adaptive immune responses including pathogen elimination and tumor immunosurveillance. Activation of the T cell receptor (TCR) pathway in naive and effector T cells leads to T cell activation, proliferation, and cytokine production.

The development of drugs and therapies regulating TCR activity require assays to profile T cell function and health. To address the need for rapid monitoring of T cell function, Sartoriuos have developed a high-content, multiplexed assay using high throughput flow cytometry to measure T cell activation (TCA).

Download this application note to discover how to:

• Rapidly monitor of T cell function
• Perform long-term activation assays and phenotypic drug discovery with the TCA kit